2H-Indol-2-one, 6-bromo-5-fluoro-1,3-dihydro-

2H-Indol-2-one, 6-bromo-5-fluoro-1,3-dihydro- - Names and Identifiers

Name	6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one
Synonyms	6-Bromo-5-fluoro-2-indolinone 6-BROMO-5-FLUOROINDOLIN-2-ONE 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one 2H-Indol-2-one, 6-bromo-5-fluoro-1,3-dihydro-
CAS	893620-44-5
InChI	InChI=1S/C8H5BrFNO/c9-5-3-7-4(1-6(5)10)2-8(12)11-7/h1,3H,2H2,(H,11,12)

2H-Indol-2-one, 6-bromo-5-fluoro-1,3-dihydro- - Physico-chemical Properties

Molecular Formula	C8H5BrFNO
Molar Mass	230.03
Density	1.749±0.06 g/cm3(Predicted)
Boling Point	334.4±42.0 °C(Predicted)
pKa	12.04±0.20(Predicted)
Storage Condition	Sealed in dry,Room Temperature

2H-Indol-2-one, 6-bromo-5-fluoro-1,3-dihydro- - Introduction

6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one is an organic compound with the formula C8H5BrFNO. The following is a description of its nature, use, formulation and safety information:

Nature:
-Appearance: 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one is a solid, often white or white-like crystalline material.
-Melting point: about 80-82°C.
-Solubility: Soluble in some organic solvents, such as ethanol, dichloromethane and acetonitrile.

Use:
6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one has certain application values in the fields of medicine and chemistry, including:
-Anticancer drug research: It is used for the synthesis of anticancer drugs and for anticancer drug related research.
-Biomarker studies: The compounds can be used as precursors for biomarkers.
-Indoline compounds: Indoline is an important class of compounds, they have a wide range of biological activities and potential pharmaceutical applications, 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one can be used as the starting point for the study and synthesis of indoline compounds.

Preparation Method:
The preparation method of 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one includes the following steps:
1.5-fluorine -1,3-diphenyl -2-indolone and ammonium bromide reaction, generation of 6-bromo -5-fluoroindolone.
2. The generated 6-bromo-5-fluoroindolone is further treated under alkaline conditions to generate 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one.

Safety Information:
- 6-Bromo-5-fluoro-1,3-dihydro-2H-indol-2-one is an organic compound, and you need to pay attention to safe operation when using it.
-It may be irritating to the skin and eyes, and should be rinsed with plenty of water immediately after contact.
-Personal protective equipment such as lab gloves, goggles and lab coats should be used during operation.
-Should be stored in a cool, dry place, away from fire and flammable substances.
-In use or handling, should follow the correct laboratory safety procedures.

Last Update：2024-04-09 19:05:52